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Incorporation of Boron in Mesoporous Bioactive Glass Nanoparticles Reduces Inflammatory Response and Delays Osteogenic Differentiation
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2020-06-02 , DOI: 10.1002/ppsc.202000054 Kai Zheng 1 , Yuqian Fan 1 , Elisa Torre 2 , Preethi Balasubramanian 1 , Nicola Taccardi 3 , Clara Cassinelli 2 , Marco Morra 2 , Giorgio Iviglia 2 , Aldo R. Boccaccini 1
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2020-06-02 , DOI: 10.1002/ppsc.202000054 Kai Zheng 1 , Yuqian Fan 1 , Elisa Torre 2 , Preethi Balasubramanian 1 , Nicola Taccardi 3 , Clara Cassinelli 2 , Marco Morra 2 , Giorgio Iviglia 2 , Aldo R. Boccaccini 1
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Mesoporous bioactive glass nanoparticles (MBG) are multifunctional building blocks for tissue regeneration and nanomedicine applications. Incorporation of biologically active ions can endow MBG with additional functionalities toward promoted therapeutic effects. Here, boron is incorporated into MBG by using a sol–gel approach. The concentration of boron incorporated is controllable by tuning the amount of boron precursor. Two types of boron‐doped MBG, namely 10B‐ and 15B‐MBG (5.8 and 6.5 mol% of B2O3, respectively) are synthesized. Boron incorporation does not significantly influence the particle morphology. All synthesized particles exhibit a sphere‐like shape with a size ranging from 100 to 300 nm. 10B‐ and 15B‐MBG show large specific surface area (346 and 320 m² g−1, respectively) and pore volume. Both boron‐doped MBG exhibit remarkable in vitro bioactivity and noncytotoxicity. Boron incorporation is shown to reduce the inflammatory response linked to macrophages as indicated by downregulated expression of pro‐inflammatory genes. However, boron incorporation delays the osteogenic differentiation in osteoblasts as indicated by the downregulated expression of pro‐osteogenic genes. The results demonstrate the promising potential of using boron‐doped MBG to modulate inflammatory response for bone regeneration under inflammatory conditions, as shown in this study for the first time.
中文翻译：
在介孔生物活性玻璃纳米颗粒中掺入硼减少炎症反应并延迟成骨分化
介孔生物活性玻璃纳米颗粒（MBG）是用于组织再生和纳米医学应用的多功能构建基块。掺入生物活性离子可以使MBG具有增强治疗效果的附加功能。在这里，通过溶胶-凝胶法将硼掺入MBG中。掺入的硼的浓度可通过调整硼前体的量来控制。合成了两种类型的硼掺杂MBG，即10B-MBG和15B-MBG（分别为B 2 O 3的5.8和6.5 mol％）。硼掺入不会显着影响颗粒形态。所有合成的颗粒均呈球形，大小范围为100至300 nm。10B‐和15B‐MBG显示较大的比表面积（346和320m²g -1）和孔体积。两种硼掺杂的MBG均具有出色的体外生物活性和非细胞毒性。硼的掺入可减少与巨噬细胞有关的炎症反应，如促炎基因表达下调所示。但是，硼的掺入延迟了成骨细胞的成骨分化，这由促成骨基因的表达下调所表明。该结果首次证明了在炎性条件下使用掺硼的MBG调节炎症反应以促进骨骼再生的潜在潜力，如本研究首次显示。
更新日期：2020-06-02
中文翻译：
在介孔生物活性玻璃纳米颗粒中掺入硼减少炎症反应并延迟成骨分化
介孔生物活性玻璃纳米颗粒（MBG）是用于组织再生和纳米医学应用的多功能构建基块。掺入生物活性离子可以使MBG具有增强治疗效果的附加功能。在这里，通过溶胶-凝胶法将硼掺入MBG中。掺入的硼的浓度可通过调整硼前体的量来控制。合成了两种类型的硼掺杂MBG，即10B-MBG和15B-MBG（分别为B 2 O 3的5.8和6.5 mol％）。硼掺入不会显着影响颗粒形态。所有合成的颗粒均呈球形，大小范围为100至300 nm。10B‐和15B‐MBG显示较大的比表面积（346和320m²g -1）和孔体积。两种硼掺杂的MBG均具有出色的体外生物活性和非细胞毒性。硼的掺入可减少与巨噬细胞有关的炎症反应，如促炎基因表达下调所示。但是，硼的掺入延迟了成骨细胞的成骨分化，这由促成骨基因的表达下调所表明。该结果首次证明了在炎性条件下使用掺硼的MBG调节炎症反应以促进骨骼再生的潜在潜力，如本研究首次显示。
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