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Synthesis of Isofagomine Derivatives as New Fluorescence pH Indicators/Glycosidase Inhibitors
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-06-02 , DOI: 10.1002/ejoc.202000522
Bo Wang 1 , Sidsel Ammitzbøll Bogh 1 , Jens Christian Navarro Poulsen 1 , Bo W. Laursen 1 , Mikael Bols 1
Affiliation  

To check the pH conditions in the active site of an enzyme an inhibitor with on/off fluorescence upon protonation is required. Herein, the potent glycosidase inhibitor isofagomine is converted into “glycosidase fluorescence indicator”.
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中文翻译:

合成新型荧光pH指示剂/糖苷酶抑制剂异黄酮衍生物

为了检查酶活性位点的pH条件,需要质子化时具有开/关荧光的抑制剂。在此,将有效的糖苷酶抑制剂异黄酮转化为“糖苷酶荧光指示剂”。
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更新日期:2020-07-08
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