Metal‐to‐Ligand Charge Transfer Chirality Sensing of d‐Glucose Assisted with GOX‐Based Enzymatic Reaction,Advanced Materials Technologies

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Metal‐to‐Ligand Charge Transfer Chirality Sensing of d‐Glucose Assisted with GOX‐Based Enzymatic Reaction
Advanced Materials Technologies ( IF 6.4 ) Pub Date : 2020-06-02 , DOI: 10.1002/admt.202000138
Junjie Hao _{1,

2,

3} , Yiwen Li ₁ , Xiaoqian Xu ₄ , Fenghuan Zhao ₂ , Ruikun Pan ₁ , Junzi Li ₅ , Haochen Liu ₃ , Kai Wang ₃ , Jiagen Li ₆ , Xi Zhu ₆ , Marie‐Hélène Delville ₂ , Ming Zhang ₁ , Tingchao He ₅ , Jiaji Cheng ₁

Affiliation

Chiral transition metal oxides nanoparticles (NPs) with tunable optical properties are widely accepted as promising toolbox for chiral recognition, stereoselective synthesis, and chiroptical devices. Herein, chirality‐based strategy is presented for discrimination of d ‐glucose from its enantiomer through a cooperative synergy between chiral cysteine capped MoO₂ NPs and the glucose oxidase nanosystem. The valence‐state‐dependent chirality induced by metal‐ligand charge transfer effect is found to be ultrasensitive to its redox environment such as the presence of hydrogen peroxide, which is a key indicator of the stereoselective enzymatic reaction between glucose oxidase and d ‐glucose. With this know‐how, glucose enantiomers can be precisely quantified with a limit of detection of 0.446 µm . Such a chiral bio‐nanosystem would be an ideal platform for a rational design of new types of biosensors, photocatalysts, and chirality‐based nanodevices.

中文翻译：

基于GOX的酶促反应对d-葡萄糖的金属到配体的电荷转移手性传感

具有可调光学性能的手性过渡金属氧化物纳米颗粒（NPs）被广泛接受为用于手性识别，立体选择性合成和手性疗法设备的有前途的工具箱。本文中，提出了一种基于手性的策略，通过手性半胱氨酸封端的MoO ₂ NP与葡萄糖氧化酶纳米系统之间的协同作用，从其对映异构体中区分d-葡萄糖。发现由金属-配体电荷转移效应诱导的价态依赖的手性对其氧化还原环境（如过氧化氢）超敏感，这是葡萄糖氧化酶与d立体选择性酶促反应的关键指标-葡萄糖。有了这种专业知识，就可以精确定量葡萄糖对映体，检出限为0.446 µm。这样的手性生物纳米系统将是合理设计新型生物传感器，光催化剂和基于手性的纳米器件的理想平台。

更新日期：2020-07-10

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