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Multifunctional STING-Activating Mn3 O4 @Au-dsDNA/DOX Nanoparticle for Antitumor Immunotherapy.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-06-02 , DOI: 10.1002/adhm.202000064 Min Zhou 1 , Xiaoyu Wang 1 , Shichao Lin 1 , Yuan Cheng 1 , Sheng Zhao 1 , Junshu Lin 1, 2 , Zhuoyao Fang 3 , Zhangping Lou 1 , Li Qin 1 , Hui Wei 1, 4
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-06-02 , DOI: 10.1002/adhm.202000064 Min Zhou 1 , Xiaoyu Wang 1 , Shichao Lin 1 , Yuan Cheng 1 , Sheng Zhao 1 , Junshu Lin 1, 2 , Zhuoyao Fang 3 , Zhangping Lou 1 , Li Qin 1 , Hui Wei 1, 4
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The promise of immunotherapy for cancer therapy has not been fully fulfilled because portions of tumors are immunosuppressive. To tackle this challenge, the initiation of immune system by stimulator of interferon genes (STING) pathway is explored and multifunctional STING‐activating nanoparticles are rationally designed for synergistic antitumor therapy. The STING‐activating nanoparticles have a formulation of Mn3O4@Au‐dsDNA/DOX, where dsDNA is used to activate STING for immunotherapy and doxorubicin (DOX) is chosen as a model drug for chemotherapy. The STING‐mediated immunity is activated, inducing interferon‐β (IFN‐β) production, increasing T cell priming, and enhancing effector T cell infiltration. Combined with chemotherapy, STING‐mediated immunotherapy shows good antitumor efficacy by inhibiting tumor growth and prolonging survival rate in vivo. The promise of cancer immunotherapy can be fulfilled by combining novel antitumor immunity with innovative nanotechnology, and chemotherapy and targeted therapies.
中文翻译：
多功能STING活化Mn3 O4 @ Au-dsDNA / DOX纳米颗粒，用于抗肿瘤免疫治疗。
The promise of immunotherapy for cancer therapy has not been fully fulfilled because portions of tumors are immunosuppressive. To tackle this challenge, the initiation of immune system by stimulator of interferon genes (STING) pathway is explored and multifunctional STING‐activating nanoparticles are rationally designed for synergistic antitumor therapy. The STING‐activating nanoparticles have a formulation of Mn3O4@ Au‐dsDNA / DOX，其中使用dsDNA激活STING进行免疫治疗，并选择阿霉素（DOX）作为化学疗法的模型药物。STING介导的免疫被激活，诱导干扰素-β（IFN-β）的产生，增加T细胞的启动，并增强效应T细胞的浸润。与化学疗法相结合，STING介导的免疫疗法可通过抑制肿瘤生长和延长体内存活率显示出良好的抗肿瘤功效。通过将新型抗肿瘤免疫与创新的纳米技术，化学疗法和靶向疗法相结合，可以实现癌症免疫疗法的希望。
更新日期：2020-07-08
中文翻译：
多功能STING活化Mn3 O4 @ Au-dsDNA / DOX纳米颗粒，用于抗肿瘤免疫治疗。
The promise of immunotherapy for cancer therapy has not been fully fulfilled because portions of tumors are immunosuppressive. To tackle this challenge, the initiation of immune system by stimulator of interferon genes (STING) pathway is explored and multifunctional STING‐activating nanoparticles are rationally designed for synergistic antitumor therapy. The STING‐activating nanoparticles have a formulation of Mn3O4@ Au‐dsDNA / DOX，其中使用dsDNA激活STING进行免疫治疗，并选择阿霉素（DOX）作为化学疗法的模型药物。STING介导的免疫被激活，诱导干扰素-β（IFN-β）的产生，增加T细胞的启动，并增强效应T细胞的浸润。与化学疗法相结合，STING介导的免疫疗法可通过抑制肿瘤生长和延长体内存活率显示出良好的抗肿瘤功效。通过将新型抗肿瘤免疫与创新的纳米技术，化学疗法和靶向疗法相结合，可以实现癌症免疫疗法的希望。
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