Injectable Functional Biomaterials for Minimally Invasive Surgery.,Advanced Healthcare Materials

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Injectable Functional Biomaterials for Minimally Invasive Surgery.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-06-02 , DOI: 10.1002/adhm.202000349
Maria Grazia Raucci ₁ , Ugo D'Amora ₁ , Alfredo Ronca ₁ , Luigi Ambrosio ₁

Affiliation

Injectable materials represent very attractive ready‐to‐use biomaterials for application in minimally invasive surgical procedures. It is shown that this approach to treat, for example, vertebral fracture, craniofacial defects, or tumor resection has significant clinical potential in the biomedical field. In the last four decades, calcium phosphate cements have been widely used as injectable materials for orthopedic surgery due to their excellent properties in terms of biocompatibility and osteoconductivity. However, few clinical studies have demonstrated certain weaknesses of these cements, which include high viscosity, long degradation time, and difficulties being manipulated. To overcome these limitations, the use of sol‐gel technology has been investigated, which has shown good results for synthesis of injectable calcium phosphate‐based materials. In the last few decades, injectable hydrogels have gained increasing attention owing to their structural similarities with the extracellular matrix, easy process conditions, and potential applications in minimally invasive surgery. However, the need to protect cells during injection leads to the development of double network injectable hydrogels that are capable of being cross‐linked in situ. This review will provide the current state of the art and recent advances in the field of injectable biomaterials for minimally invasive surgery.

中文翻译：

用于微创手术的可注射功能性生物材料。

可注射材料代表了非常有吸引力的即用型生物材料，可用于微创外科手术。结果表明，这种治疗椎骨骨折，颅面缺损或肿瘤切除的方法在生物医学领域具有重要的临床潜力。在过去的四十年中，由于磷酸钙水泥在生物相容性和骨传导性方面的优异性能，已被广泛用作骨科手术的可注射材料。但是，很少有临床研究证明这些胶粘剂的某些缺点，包括高粘度，较长的降解时间和难以操作。为了克服这些限制，已经研究了溶胶凝胶技术的使用，在合成可注射磷酸钙基材料方面显示出了良好的效果。在过去的几十年中，可注射水凝胶由于其与细胞外基质的结构相似性，易加工的条件以及在微创手术中的潜在应用而受到越来越多的关注。然而，在注射过程中保护细胞的需求导致了能够在原位交联的双网络可注射水凝胶的发展。这篇综述将提供用于微创手术的可注射生物材料领域的当前技术水平和最新进展。及其在微创手术中的潜在应用。然而，在注射过程中保护细胞的需求导致了能够在原位交联的双网络可注射水凝胶的发展。这篇综述将提供用于微创手术的可注射生物材料领域的当前技术水平和最新进展。及其在微创手术中的潜在应用。然而，在注射过程中保护细胞的需求导致了能够在原位交联的双网络可注射水凝胶的发展。这篇综述将提供用于微创手术的可注射生物材料领域的当前技术水平和最新进展。

更新日期：2020-07-08

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