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Effects of pyriproxyfen exposure on immune signaling pathway and transcription of detoxification enzyme genes in fat body of silkworm, Bombyx mori
Pesticide Biochemistry and Physiology ( IF 4.2 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.pestbp.2020.104621 Guodong Zhao 1 , Huimin Guo 2 , Haitao Zhang 2 , Xiao Zhang 2 , Heying Qian 1 , Gang Li 1 , Anying Xu 1
Pesticide Biochemistry and Physiology ( IF 4.2 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.pestbp.2020.104621 Guodong Zhao 1 , Huimin Guo 2 , Haitao Zhang 2 , Xiao Zhang 2 , Heying Qian 1 , Gang Li 1 , Anying Xu 1
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Sericulture is a very important and flourishing industry in developing countries. Bombyx mori is a kind of important and well-studied economic insects in the whole world. In China, applying of pyriproxyfen pesticide often resulted in non-cocooning and silk yield reduction. However, the effects of pyriproxyfen exposure on immune signaling pathway in fat body of silkworm has not been reported yet now. In the present study, we found that the growth and development of silkworm were significantly affected by pyriproxyfen exposure and the fat body tissues were injured after treatment. It was also showed that the expressions of key genes of PI3K/Akt and CncC/Keap1 pathway can be elevated at 24-96 h after pyriproxyfen exposure. Furtherly, the relative expression levels of detoxification enzyme genes and the activities of detoxification enzymes were both increased by pyriproxyfen exposure. These results provided comprehensive view of fat body injury and gene expression changes in silkworm after pyriproxyfen exposure.
更新日期：2020-09-01
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