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Brain Weight and Cognitive Abilities of Laboratory Mice
Biology Bulletin Reviews Pub Date : 2020-04-10 , DOI: 10.1134/s2079086420020061
O. V. Perepelkina , A. Yu. Tarasova , N. A. Ogienko , I. G. Lil’p , I. I. Poletaeva

Abstract

Differences in brain weight, a morphological trait associated with the level of animal cognition, is usually evaluated via comparison of the respective scores in animals of different taxa. Selection for large and small brain size (in laboratory mice) is a technique that allows this role to be evaluated at the level of intraspecies variability. Selection for contrasting values of this trait were stopped at the level of F22, and lines with large and small brain weight were randomly bred inside each line. It was found that brain weight and behavioral differences (the prevalence of large brains in the solution of cognitive tasks) between these lines were maintained without selection. At the same time, selection for high scores of cognitive-task solution resulted in higher brain-weight scores in the selected strain. Therefore, in laboratory mice (widely used by neurobiologists as a model) the brain weight values could be the indicator of cognitive capacities development.


中文翻译:

实验小鼠的脑重量和认知能力

摘要

脑重量的差异是与动物认知水平相关的形态特征,通常通过比较不同分类群动物的相应得分来评估。选择大脑大小的动物(在实验小鼠中)是一种可以在种内变异性水平上评估此作用的技术。在F22的水平上停止选择该性状的对比值,并在每条线内随机繁殖大小脑重量的线。发现在不选择的情况下,这些系之间的脑重量和行为差异(认知任务解决方案中大脑的流行)得以维持。同时,对高分认知任务解决方案的选择导致所选菌株的脑重量得分更高。因此,
更新日期:2020-04-10
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