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Suppression of Bacterial Adhesion: Modern Approaches, Problems, and Prospects
Biology Bulletin Reviews Pub Date : 2020-04-10 , DOI: 10.1134/s2079086420020036 G. G. Kharseeva , A. Yu. Mironov , A. A. Alieva
中文翻译:
抑制细菌粘附:现代方法,问题和前景。
更新日期:2020-04-10
Biology Bulletin Reviews Pub Date : 2020-04-10 , DOI: 10.1134/s2079086420020036 G. G. Kharseeva , A. Yu. Mironov , A. A. Alieva
Abstract
The paper analyzes problems related to bacterial infections and modern approaches to the suppression of bacterial adhesion. The development of an infection depends upon the pathogen’s ability to colonize the surface of epithelial cells of the host organism and to reach the deeper tissues and organs. The initial stage in the development of any bacterial infection is manifested in pathogenic attachment—microbial adhesion to the surface of host cells. The adhesion specificity is due to the presence of complementary microbial structures and eukaryotic host cells sensitive to them. The development of infection may be stopped during any of its stages. To interrupt infection during the initial phase, i.e., adhesion, one promising solution is the use of various types of antiadhesive therapy (subinhibitory doses of antibacterial drugs, enzyme inhibitors, sugars, glycomimetics, peptide-like substances, cranberry juice, juniper extract, etc.). Adhesion may also be inhibited by the administration of vaccines that stimulate the production of specific antibodies to bacterial adhesins or ready-made antibodies in the form of commercial products containing antisera or immunoglobulins. The development of modern approaches to the interruption of microorganic adhesion with antiadhesive therapy agents is an efficient method for the treatment and prevention of bacterial infections, particularly those caused by microorganisms polyresistant to antimicrobial chemotherapeutical drugs.中文翻译:
抑制细菌粘附:现代方法,问题和前景。