Abstract

The paper analyzes problems related to bacterial infections and modern approaches to the suppression of bacterial adhesion. The development of an infection depends upon the pathogen’s ability to colonize the surface of epithelial cells of the host organism and to reach the deeper tissues and organs. The initial stage in the development of any bacterial infection is manifested in pathogenic attachment—microbial adhesion to the surface of host cells. The adhesion specificity is due to the presence of complementary microbial structures and eukaryotic host cells sensitive to them. The development of infection may be stopped during any of its stages. To interrupt infection during the initial phase, i.e., adhesion, one promising solution is the use of various types of antiadhesive therapy (subinhibitory doses of antibacterial drugs, enzyme inhibitors, sugars, glycomimetics, peptide-like substances, cranberry juice, juniper extract, etc.). Adhesion may also be inhibited by the administration of vaccines that stimulate the production of specific antibodies to bacterial adhesins or ready-made antibodies in the form of commercial products containing antisera or immunoglobulins. The development of modern approaches to the interruption of microorganic adhesion with antiadhesive therapy agents is an efficient method for the treatment and prevention of bacterial infections, particularly those caused by microorganisms polyresistant to antimicrobial chemotherapeutical drugs.

中文翻译：

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抑制细菌粘附：现代方法，问题和前景。

摘要

本文分析了与细菌感染有关的问题以及抑制细菌粘附的现代方法。感染的发展取决于病原体在宿主生物的上皮细胞表面定殖并到达更深的组织和器官的能力。任何细菌感染的发展的初始阶段都表现在病原体附着上-微生物粘附在宿主细胞表面。粘附特异性是由于存在互补的微生物结构和对它们敏感的真核宿主细胞。感染的发展可以在任何阶段停止。为了在初始阶段即粘连中中断感染，一种有前途的解决方案是使用各种类型的抗粘连疗法（亚抑制剂量的抗菌药物，酶抑制剂，糖，模拟糖，类肽物质，酸果蔓汁，杜松提取物等）。也可以通过施用刺激细菌特异性粘附力的疫苗来抑制粘附，所述特异性抗细菌粘附素或现成抗体的形式以包含抗血清或免疫球蛋白的商品形式出现。用抗粘连治疗剂破坏微生物粘连的现代方法的发展是一种有效的方法，用于治疗和预防细菌感染，尤其是那些由对抗菌化学药物有多药耐药性的微生物引起的细菌感染。也可以通过施用刺激细菌特异性粘附力的疫苗来抑制粘附，所述特异性抗细菌粘附素或现成抗体的形式以包含抗血清或免疫球蛋白的商品形式出现。用抗粘连治疗剂破坏微生物粘连的现代方法的发展是一种有效的方法，用于治疗和预防细菌感染，尤其是那些由对抗菌化学药物有多药耐药性的微生物引起的细菌感染。也可以通过施用刺激细菌特异性粘附力的疫苗来抑制粘附，所述特异性抗细菌粘附素或现成抗体的形式以包含抗血清或免疫球蛋白的商品形式出现。用抗粘连治疗剂破坏微生物粘连的现代方法的发展是一种有效的方法，用于治疗和预防细菌感染，尤其是那些由对抗菌化学药物有多药耐药性的微生物引起的细菌感染。