A three-dimensional unsteady periodic flow of blood in xenogenic vascular bioprostheses is simulated by computational fluid dynamics methods. The geometry of the computational domain is based on microtomographic scanning of bioprostheses. To set a variable pressure gradient causing an unsteady flow in the prostheses, personal-specific data of the Doppler echography of the blood flow of a particular patient are used. A comparative analysis of the velocity fields in the flow areas corresponding to three real samples of bioprostheses with multiple stenoses is carried out. In the zones of stenosis and outside of them, the distribution of the near-wall shear stress, which affects the risk factors for thrombosis in the prostheses, is analyzed. An algorithm for predicting the hemodynamic effects arising in vascular bioprostheses is proposed; the algorithm is based on the numerical modeling of the blood flow in these prostheses.

中文翻译：

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预测血管假体血流动力学效应的数值方法

通过计算流体动力学方法模拟异种血管生物假体中的三维非定常周期性血流。计算域的几何结构是基于生物假体的显微断层扫描。为了设置导致假体不稳定流动的可变压力梯度，使用了特定患者血流的多普勒超声检查的个人特定数据。对流场中的速度场进行了比较分析，该流场对应于具有多个狭窄的三个生物假体的真实样本。在狭窄区域及其外部，分析了影响假体血栓形成危险因素的近壁剪切应力的分布。提出了一种预测血管生物假体产生的血液动力学效应的算法。