Abstract

Aging organisms die out in accordance with the “Gompertz law,” i.e., the probability of their death increases with age. Survival curve construction is the main tool for gerontologists to study aging and test antiaging drugs. The analysis of survival curves includes obtaining some indices characterizing aging of the population, for example, the average and maximum lifespan, the mortality rate, and the aging rate. Testing geroprotectors can be correctly performed only by obtaining such curves. The dying out of stationary cell populations—bacteria, yeast, and mammalian cell cultures—also occurs in accordance with the Gompertz equation. In this regard, it is reasonable to use the construction of survival curves and their analysis to study the “aging” of non-subcultured cell cultures and testing anti-aging drugs on them. We used this approach in our experiments, due to which we were able to detect the positive anti-aging effect of the Quinton Marine Plasma on stationary phase aging culture of Chinese hamster cells.

中文翻译：

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研究细胞培养老化的人口统计学方法

摘要

衰老的生物按照“ Gompertz定律”消亡，即其死亡的可能性随着年龄的增长而增加。生存曲线的构建是老年学家研究衰老和测试抗衰老药物的主要工具。生存曲线的分析包括获得一些表征人口老龄化的指标，例如平均寿命和最大寿命，死亡率和老龄化率。只有通过获得这样的曲线，才能正确地测试防油保护器。静止细胞群（细菌，酵母和哺乳动物细胞培养物）的死亡也按照Gompertz方程发生。在这方面，使用存活曲线的构建及其分析来研究非传代细胞培养物的“衰老”并在其上测试抗衰老药物是合理的。