Abstract — Cisplatin is an effective anticancer drug used to treat various types of cancer. The main disadvantage of the drug is its high toxicity. To reduce the toxic effect of cisplatin, we conjugated it with arabinogalactan, which is capable of forming soluble globules and bind poorly soluble pharmacological compounds by confining them inside spheroid globules. In this study, we compared the biological effect and mechanism of action of cisplatin and its complex with arabinogalactan (AG–Pt) on the growth of Ehrlich ascites carcinoma in vivo. It has been shown that the conjugates of arabinogalactan with cisplatin exerted a strong antitumor effect despite the fact that the dose of cisplatin in the composition of the conjugates was 10 times less than the standard dose. At the same time, the conjugates of arabinogalactan with cisplatin were virtually nontoxic. It has been established that the antitumor effect of cisplatin and its conjugates with arabinogalactan is due to the induction of apoptosis in tumor cells. It is assumed that a decrease in toxicity and an increase in the efficacy of cisplatin-arabinogalactan conjugates compared to pure cisplatin are associated with its more efficient accumulation in tumor cells.

中文翻译：

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通过与阿拉伯半乳聚糖结合降低顺铂的毒性

摘要 — 顺铂是一种有效的抗癌药物，用于治疗多种癌症。该药物的主要缺点是其高毒性。为了减少顺铂的毒性作用，我们将其与阿拉伯半乳聚糖结合，后者能够形成可溶性小球并通过将它们限制在球状小球内来结合难溶性药理学化合物。在这项研究中，我们比较了顺铂及其与阿拉伯半乳聚糖（AG-Pt）的复合物对体内艾氏腹水癌生长的生物学效应和作用机制。已经表明，尽管缀合物组合物中顺铂的剂量比标准剂量小 10 倍，但阿拉伯半乳聚糖与顺铂的缀合物仍发挥了强大的抗肿瘤作用。同时，阿拉伯半乳聚糖与顺铂的结合物实际上是无毒的。已经确定顺铂及其与阿拉伯半乳聚糖结合物的抗肿瘤作用是由于诱导肿瘤细胞凋亡。据推测，与纯顺铂相比，顺铂-阿拉伯半乳聚糖偶联物的毒性降低和功效增加与其在肿瘤细胞中更有效的积累有关。