Abstract

The endothelium of blood vessels plays an important role in the regulation of normal and pathological processes occurring in the tissues. Monoclonal antibodies (MAbs) to endoglin (CD105), a marker of endothelial cells, are considered as potential agents to affect the functional characteristics of endothelial cells. Here, we report the ability of MAbs against several epitopes of endoglin to modify the functional characte-ristics of human EA.hy926 endothelial cells in vitro. Different MAbs were found to slow down cell proliferation or migration, to increase the adhesion of monocyte-like cells, or to reduce the rate of soluble endoglin accumulation in a culture medium. Two MAbs of the eight studied reagents were able to affect several functional characteristics of endothelial cells.

中文翻译：

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单克隆抗体对人内皮糖蛋白的影响对EA.hy926内皮细胞功能特性的影响

摘要

血管的内皮在调节组织中发生的正常和病理过程中起重要作用。抗内皮糖蛋白（CD105）（内皮细胞的标志物）的单克隆抗体（MAb）被认为是影响内皮细胞功能特性的潜在药物。在这里，我们报告单克隆抗体对内皮糖蛋白的几个表位修改体外人EA.hy926内皮细胞的功能特性的能力。发现不同的MAb减慢细胞增殖或迁移，增加单核细胞样细胞的粘附，或降低培养基中可溶性内皮糖蛋白的积累速率。八种研究试剂中的两种单克隆抗体能够影响内皮细胞的几种功能特性。