Abstract —Here, we consider the problem of the activation of the complement system by amyloid aggregates, in particular, amyloid fibrils of the Aβ(1-40) and Aβ(1-42) peptides found in the brain of patients with Alzheimer’s disease . In 1992, based on the data on colocalization of amyloid inclusions with complement system proteins in the brains of patients with this disease, it was suggested that this system is directly activated by amyloids. This hypothesis has been supported by a number of subsequent publications. However, in this study, we did not find evidence to support this idea. The issue remains as to whether amyloids activate the complement system, and, if not, which mechanism is responsible for its activation. Here, we try to elucidate these issues.

中文翻译：

---

Aβ(1-40) 和 Aβ(1-42) 肽的淀粉样蛋白聚集体激活补体系统：事实和假设

摘要——在这里，我们考虑了淀粉样蛋白聚集体激活补体系统的问题，特别是在阿尔茨海默病患者大脑中发现的 Aβ(1-40) 和 Aβ(1-42) 肽的淀粉样原纤维。1992年，根据本病患者大脑中淀粉样蛋白内含物与补体系统蛋白共定位的数据，有人提出该系统是由淀粉样蛋白直接激活的。这一假设得到了许多后续出版物的支持。然而，在这项研究中，我们没有找到支持这个想法的证据。问题仍然是淀粉样蛋白是否激活补体系统，如果没有，哪个机制负责其激活。在这里，我们试图阐明这些问题。