Abstract

Two new approaches have been proposed for the synthesis of 4-hydroxy-1,4-dihydropyrazolo[5,1-c]-[1,2,4]triazines via (1) borohydride reduction of 1-R-4-oxo-1,4-dihydro derivatives and (2) Vilsmeier formylation of 3-tert-butyl-8-methylpyrazolo[5,1-c][1,2,4]triazine. 3-tert-Butylpyrazolo[5,1-c][1,2,4]triazin-1(5)-ium cation has been generated for the first time by treatment of 7-amino-1-benzyl-3-tert-butyl-4-hydroxy-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-8-carbonitrile with trifluoroacetic acid in CDCl₃. The hydrolysis of 4-alkoxy-1,4-dihydropyrazolo[5,1-c][1,2,4]triazines was monitored by ¹H and ¹³C NMR spectroscopy. The structure of the synthesized compounds was confirmed by spectral and X-ray diffraction data.

中文翻译：

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3-叔丁基-4-羟基-1,4-二氢吡唑并[5,1-c] [1,2,4]三嗪的合成

摘要

已提出了两种新方法，用于通过（1）硼氢化物还原1-R-4-氧代-（4-）-1,4-二氢吡唑并[5,1- c ]-[1,2,4]三嗪1,4-二氢衍生物和（2）3-叔丁基-8-甲基吡唑并[5,1- c ] [1,2,4]三嗪的Vilsmeier甲酰化。3-叔-Butylpyrazolo [5,1- c ^ ] [1,2,4]三嗪-1（5）阳离子鎓已通过治疗的7-氨基-1-苄基-3-首次生成的叔-丁基-4-羟基-1,4-二氢吡唑并[5,1- c ] [1,2,4]三嗪-8-腈与三氟乙酸的CDCl ₃溶液。用¹监测4-烷氧基-1,4-二氢吡唑并[5,1- c ] [1,2,4]三嗪的水解。1 H和¹³ C NMR光谱。合成的化合物的结构通过光谱和X射线衍射数据证实。