Abstract

We describe the role of genomic and postgenomic technologies in the study of the preeclampsia genetic architecture in this review. Preeclampsia is a severe hypertensive disease of pregnancy that causes a significant level of maternal and perinatal morbidity and mortality. We emphasize the importance of integrative analysis of genomic, methylomic, transcriptomic, and proteomic data for characterizing the molecular mechanisms of preeclampsia, identifying new candidate genes and molecules for targeted therapy of this gestational complication.

中文翻译：

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先兆子痫遗传学中的基因组和后基因组技术

摘要

我们在这篇综述中描述了基因组和后基因组技术在先兆子痫遗传结构研究中的作用。子痫前症是一种严重的妊娠高血压疾病，可导致孕妇和围产期的大量发病和死亡。我们强调对基因组，甲基组，转录组和蛋白质组学数据进行综合分析对于表征先兆子痫的分子机制，鉴定新的候选基因和这种妊娠并发症的靶向治疗分子的重要性。