Abstract

Parkinson’s disease (PD) as a genetically heterogeneous disease is the second common neurological disorder which is associated with motor deficits and dementia owing to a spreading process of neuronal loss in the brain. Little is known about what affects Parkinson disease, but global efforts are underway to make medicines for treatment of this disease. We suppose, exercise as one of the golden key for overall health and brain-derived neurotrophic factor (BDNF) modulator must have some effects on the degree of PD severity. On the other hand, given the dopamine is one of the indispensable components for the endogenous morphine biosynthesis, a decrease in the level of morphine, may be associated with this disorder. We investigate the rate of true effect of exercise and morphine treatments on the expression of some major heritable genes in PD, including SNCA, LRRK2, Parkin, and DJ-1, by real-time PCR in rat hippocampus. The results indicated that under exercise and morphine treatments, the expression of alpha-synuclein and LRRK2 genes declined, while the expression of Parkin and DJ-1 genes raised. Since this genes expression pattern has been observed in the normal individuals, it can be concluded that exercise and morphine treatments have a positive effect on the improvement of Parkinson disease, and it might act in similar way in humans.

中文翻译：

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运动和吗啡对大鼠海马帕金森氏相关基因表达的影响

摘要

帕金森氏病（PD）是遗传异质性疾病，是第二种常见的神经系统疾病，由于大脑中神经元损失的扩散过程，与运动功能障碍和痴呆症相关。关于影响帕金森氏病的因素知之甚少，但全球正在努力生产用于治疗该病的药物。我们认为，运动是整体健康的金钥匙之一，而脑源性神经营养因子（BDNF）调节剂必须对PD严重程度产生一定影响。另一方面，鉴于多巴胺是内源性吗啡生物合成必不可少的成分之一，因此吗啡水平的降低可能与这种疾病有关。我们调查了运动和吗啡治疗对PD中某些主要可遗传基因表达的真实影响率，SNCA，LRRK2，Parkin和DJ-1，通过实时PCR在大鼠海马中进行。结果表明，在运动和吗啡处理下，α-突触核蛋白和LRRK2基因的表达下降，而Parkin和DJ-1基因的表达上升。由于已经在正常个体中观察到了该基因的表达模式，因此可以得出结论，运动和吗啡治疗对帕金森病的改善具有积极作用，并且可能在人类中以类似的方式起作用。