Abstract

The Tscherniac–Einhorn reaction of 6-methyl and 6-(trifluoromethyl) derivatives of 2-thiouracil with N-(bromomethyl)phthalimide in under basic catalysis leads to the formation of S-amidomethylation products. When using 6-amino-2-thiouracil, decomposition of the alkylation products occurs. An in vitro study of the compounds obtained showed their lack of cytotoxicity and anti-HIV-1/2 activity.

中文翻译：

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Tscherniac‒Einhorn与2-硫脲嘧啶衍生物的反应的一些特征

摘要

在碱性催化下2-硫尿嘧啶的6-甲基和6-（三氟甲基）衍生物与N-（溴甲基）邻苯二甲酰亚胺的Tscherniac-Einhorn反应导致形成S-酰胺甲基化产物。当使用6-氨基-2-硫尿嘧啶时，发生烷基化产物的分解。对获得的化合物的体外研究表明，它们缺乏细胞毒性和抗HIV-1 / 2活性。