Abstract

Aminomethylation of 3-methyl-3-ethylpyrrolidin-2,5-dione (ethosuximide) and 3-(4-isopropoxyphenyl)pyrrolidine-2,5-dione (pufemide) with a 25% aqueous formalin solution and alkyl(aryl)amines yielded corresponding N-aminomethyl derivatives. The antioxidant activity of the synthesized compounds and their effect on some parameters of the blood coagulation system were studied.

中文翻译：

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乙草胺和布非胺抗惊厥药的N-氨基甲基衍生物的合成及抗氧化活性

摘要

用25％的福尔马林水溶液和烷基（芳基）胺将3-甲基-3-乙基吡咯烷酮2,5-二酮（ethosuximide）和3-（4-异丙氧基苯基）吡咯烷-2,5-dione（pufemide）氨基甲基化对应ñ -氨基甲基衍生物。研究了合成化合物的抗氧化活性及其对凝血系统某些参数的影响。