Abstract

Sterically hindered amines such as triacetonamine and certain closely related analogs have been applied in medicine, pharmacology and industry. Various methods of synthesis of 2,2,6,6-tetramethylpiperidin-4-one (triacetonamine) derivatives start generally with acetone, phorone, piperidine N-oxides, piperidine alcohols, and 4-dimethylamine piperidine derivatives. Physical properties of triacetonamine including density, boiling point, flash point, and melting point have been determined. Reactions of triacetonamine derivatives with various organic reagents are also summarized. Triacetonamine derivatives react via three functional groups including carbonyl, methylenes adjacent to the carbonyl group, and NH. Some other miscellaneous reactions are presented. Conformation of triacetonamine is described. Theoretical models for the conformations of triacetonamine have been developed by quantum and molecular mechanics methods. Triacetonamine demonstrates different types of biological activities, such as antialzheimer, antifungal, antimicrobial, anti-HIV, anticancer, antioxidant, P38 kinase inhibitor, DNA labelling, antispasmodic, and psychotropic, and high ganglionic blocking.

中文翻译：

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三乙胺的合成及生物活性

摘要

立体受阻胺如三乙胺和某些密切相关的类似物已在医学，药理学和工业中应用。合成2,2,6,6-四甲基哌啶-4-一（三丙酮胺）衍生物的各种方法通常从丙酮，佛尔酮，哌啶N开始-氧化物，哌啶醇和4-二甲胺哌啶衍生物。已经确定了三乙胺的物理性质，包括密度，沸点，闪点和熔点。还总结了三乙胺衍生物与各种有机试剂的反应。三乙胺衍生物经由三个官能团反应，所述三个官能团包括羰基，与羰基相邻的亚甲基和NH。提出了其他一些其他反应。描述了三乙胺的构象。三丙酮胺构象的理论模型已经通过量子和分子力学方法得到了发展。三醋氨胺具有不同类型的生物活性，例如抗阿尔茨海默氏病，抗真菌，抗微生物，抗艾滋病毒，抗癌，抗氧化剂，P38激酶抑制剂，DNA标记，解痉，