Abstract

Some novel isoxazole-phenothiazine hybrids have been synthesized regioselectively in high yields via Cu(I) catalyzed one-pot reaction of 10-(prop-2-yn-1-yl)phenothiazine with aromatic aldehydes in aqueous butanol medium. Structures of the newly phenothiazine-isoxazole compounds have been confirmed by ¹H and ¹³C NMR, and mass spectral data. Products have been evaluated for their antibacterial activity, and few of those demonstrate high growth inhibition activity as compared against the standards drugs Penicillin-G and Streptomycin.

中文翻译：

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新型异恶唑-吩噻嗪杂化物的一锅区域选择性合成及其抗菌活性

摘要

一些新的异恶唑-吩噻嗪杂化物已经通过在丁醇水溶液中通过Cu（I）催化10-（prop-2-yn-1-yl）吩噻嗪与芳香族醛的一锅反应高选择性地合成。新的吩噻嗪-异恶唑化合物的结构已通过¹ H和¹³ C NMR以及质谱数据证实。已对产品的抗菌活性进行了评估，与标准药物Penicillin-G和Streptomycin相比，很少有产品具有高生长抑制活性。