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One-Pot Regioselective Synthesis of Some Novel Isoxazole-Phenothiazine Hybrids and Their Antibacterial Activity
Russian Journal of General Chemistry ( IF 0.9 ) Pub Date : 2020-06-04 , DOI: 10.1134/s1070363220030214 V. Guguloth , N. S. Thirukovela , S. Paidakula , R. Vadde
中文翻译:
新型异恶唑-吩噻嗪杂化物的一锅区域选择性合成及其抗菌活性
更新日期:2020-06-04
Russian Journal of General Chemistry ( IF 0.9 ) Pub Date : 2020-06-04 , DOI: 10.1134/s1070363220030214 V. Guguloth , N. S. Thirukovela , S. Paidakula , R. Vadde
Abstract
Some novel isoxazole-phenothiazine hybrids have been synthesized regioselectively in high yields via Cu(I) catalyzed one-pot reaction of 10-(prop-2-yn-1-yl)phenothiazine with aromatic aldehydes in aqueous butanol medium. Structures of the newly phenothiazine-isoxazole compounds have been confirmed by 1H and 13C NMR, and mass spectral data. Products have been evaluated for their antibacterial activity, and few of those demonstrate high growth inhibition activity as compared against the standards drugs Penicillin-G and Streptomycin.中文翻译:
新型异恶唑-吩噻嗪杂化物的一锅区域选择性合成及其抗菌活性