Abstract

Convenient preparative ways to synthesize tritium-labeled non-natural derivatives containing the cytosine and guanine moieties have been developed. The main distinction of these compounds from those already known consists in that they contain a chiral center. The tritium-labeled 2'-desoxy-3'-oxacytidine can was synthesized by the reaction of catalytic dehalogenation in solution of the corresponding 5-bromine-substituted compound; for 6-aminocyclopropyl-2'-desoxy-3'-oxaguanosine, the reaction of catalytic heterogeneous catalytic exchange in solution was used; for rest of compounds, the reaction of solid-phase catalytic hydrogenation (SCH) was employed.

中文翻译：

---

Pur标记的嘌呤和嘧啶核苷的非天然类似物的合成

摘要

已经开发了合成包含胞嘧啶和鸟嘌呤部分的tri标记的非天然衍生物的简便制备方法。这些化合物与已知化合物的主要区别在于它们包含一个手性中心。by标记的2'-脱氧-3'-氧代胞苷罐可以通过相应的5-溴取代的化合物在溶液中的催化脱卤反应来合成。对于6-氨基环丙基-2'-脱氧-3'-氧鸟嘌呤，采用溶液中催化多相催化交换的反应。对于其余化合物，采用固相催化氢化反应（SCH）。