Abstract The efficiency of controlled drug release systems is largely determined by the properties of the matrix material. Our research team developed a process for production of biodegradable polymer films based on high-molecular-weight polylactide with properties necessary for medical and agricultural applications. A process for incorporation of drugs (gentamicin sulfate, lincomycin hydrochloride, cefotaxime) into high-molecular-weight polylactide films was developed. The mechanical properties and biocompatibility of the obtained polymers were studied. The films based on high-molecular-weight polylactide were found to have high strength characteristics (yield strength of about 49 MPa, tensile strength of 54 MPa). With increasing drug concentration, the strength characteristics of polymer films linearly decrease. The biocompatibility of the polymers was demonstrated on both cell cultures and implantation into animal models.

中文翻译：

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基于高分子量聚乳酸的医药和农业生物可降解聚合物的开发：机械性能和生物相容性

摘要 药物控释系统的效率在很大程度上取决于基质材料的特性。我们的研究团队开发了一种基于高分子量聚乳酸的可生物降解聚合物薄膜的生产工艺，该薄膜具有医疗和农业应用所需的特性。开发了一种将药物（硫酸庆大霉素、盐酸林可霉素、头孢噻肟）掺入高分子量聚乳酸薄膜的工艺。研究了所得聚合物的机械性能和生物相容性。发现基于高分子量聚丙交酯的薄膜具有高强度特性（约 49 MPa 的屈服强度，54 MPa 的拉伸强度）。随着药物浓度的增加，聚合物薄膜的强度特性线性下降。