An original method for the synthesis of copper-containing nanosystems for biomedical applications using hydrazine hydrate as a reducing agent was developed. The process involves intermediate formation of the [Cu(NH3)4]2+ complex ion, which ensures the formation of Cu0 nanoparticles without oxide impurity. The 2-deoxy-2-methacrylamido-D-glucose copolymer with 2-(dimethylamino)ethyl methacrylate or bovine serum albumin was used as a macromolecular hydrophilic stabilizer. The spectral and structure-morphological characteristics of the nanosystems were studied. This stabilization resulted in an almost unimodal distribution of zerovalent copper nanoparticles in aqueous solutions due to their rather good shielding by macromolecules.

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基于高分子亲水稳定剂的含铜纳米系统

开发了一种使用水合肼作为还原剂合成用于生物医学应用的含铜纳米系统的原始方法。该过程涉及 [Cu(NH3)4]2+ 复合离子的中间形成，确保形成不含氧化物杂质的 Cu0 纳米颗粒。2-脱氧-2-甲基丙烯酰胺-D-葡萄糖与甲基丙烯酸2-（二甲氨基）乙酯或牛血清白蛋白的共聚物被用作大分子亲水稳定剂。研究了纳米系统的光谱和结构-形态特征。这种稳定导致零价铜纳米粒子在水溶液中几乎单峰分布，因为它们被大分子很好地屏蔽。