The review summarizes data on natural compounds including higher carboxylic acids, acetogenins, lembehynes, and insect pheromones containing bis-methylene-interrupted Z-double bonds in the molecules, general approaches to their synthesis, and the biological activities they exhibit. The review is of interest for a wide circle of researchers in the field of organic, medicinal, phyto- and biochemistry, and pharmacology, and pharmacognosy, as it describes the key strategies of stereoselective formation of bis-methylene-interrupted Z-double bonds, known biological activities of these natural compounds, their total synthesis, and occurrence in plants, animals, and microorganisms.

该综述总结了有关天然化合物的数据，包括在分子中包含双亚甲基间断的Z-双键的高级羧酸，产乙酸素，榄香烯和昆虫信息素，其合成的一般方法以及它们表现出的生物学活性。该综述引起了有机，药物，植物和生物化学，药理学和生药学领域的广泛研究人员的关注，因为它描述了双亚甲基间断的Z-双键立体选择性形成的关键策略，这些天然化合物的已知生物活性，它们的总合成以及在植物，动物和微生物中的存在。