A series of 2,3-diaryldibenzo[b]thiophene derivatives have been synthesized via Suzuki coupling reactions in moderate to good yields (59–79%). The synthesized compounds were evaluated for their antithrombolytic, biofilm inhibition, and hemolytic potential. All compounds showed significant biological potential. Compound (4k) revealed excellent antithrombolytic (87.24%) and biofilm inhibition (99.64%) activity. While compound (4i) exhibited an outstanding hemolytic potential (84.53%). The docking studies uncovered that studied compounds interact with streptokinase and plasminogen via hydrogen bonding, π-anion, π–π stacked interactions, and π-sigma bonding type interactions. The results revealed that synthesized benzo[b]thiophene derivatives could be a potential source of therapeutic agents.

中文翻译：

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通过钯（0）Suzuki-Miyaura交叉偶联反应有效合成2,3-二芳基苯并[b]噻吩分子及其抗血栓溶解性，生物膜抑制，溶血潜力和分子对接研究

通过Suzuki偶联反应已合成了一系列2,3-二芳基二苯并[b]噻吩衍生物，产率中等至良好（59-79％）。评价了合成的化合物的抗血栓形成，生物膜抑制和溶血潜力。所有化合物均显示出显着的生物学潜力。化合物（4k）具有出色的抗血栓溶解性（87.24％）和生物膜抑制作用（99.64％）。虽然复合（4i）具有出色的溶血潜力（84.53％）。对接研究发现，所研究的化合物通过氢键，π阴离子，π-π堆积相互作用和π-sigma键类型相互作用与链激酶和纤溶酶原相互作用。结果表明，合成的苯并[b]噻吩衍生物可能是治疗剂的潜在来源。