Abstract β-Cyclodextrin based nanosponges have been synthesized in three molar ratios, and characterized by phase solubility studies, Fourier-transform infrared spectroscopy, matrix-assisted laser desorption/ionization time of flight mass spectrometry, and scanning electron microscopy. Following characterization studies, a model anti-bacterial agent, sulfamethoxazole, has been loaded within the nanosponges, and in vitro drug release studies were carried out. According to results, nanosponges below ~ 100 nm diameter were obtained with a characteristic sponge-like morphology. Phase solubility studies demonstrated that β-cyclodextrin nanosponges improve solubility of the drug up to 30-fold. These results suggest that nanosponges could improve the bioavailability of drugs by conducing them to reach desired plasma concentrations for therapeutic effect. Graphic abstract

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用于磺胺甲恶唑给药的环糊精纳米海绵的制备和表征研究

摘要 β-环糊精基纳米海绵以三种摩尔比合成，并通过相溶解度研究、傅里叶变换红外光谱、基质辅助激光解吸/电离飞行时间质谱和扫描电子显微镜进行表征。在表征研究之后，一种模型抗菌剂磺胺甲恶唑已装入纳米海绵中，并进行了体外药物释放研究。根据结果​​，获得了直径小于 100 nm 的纳米海绵，具有特征性的海绵状形态。相溶解度研究表明，β-环糊精纳米海绵可将药物的溶解度提高 30 倍。这些结果表明，纳米海绵可以通过引导药物达到治疗效果所需的血浆浓度来提高药物的生物利用度。