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Lipids in ultraviolet radiation-induced immune modulation.
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2020-06-02 , DOI: 10.1039/d0pp00146e
Benita C Y Tse 1 , Scott N Byrne 1, 2
Affiliation  

Ultraviolet (UV) radiation-mediated immune suppression is a key mechanism conferring both detrimental and beneficial impacts of sun exposure on human health. Suppression of anti-tumour responses promotes the development and progression of UV-induced skin cancers. In contrast, suppression of dysregulated immune responses facilitate the therapeutic success of phototherapy treatment for skin disorders and is postulated to be responsible for UV protection from autoimmune diseases. While some of the molecular and cellular mechanisms underlying UV-suppression of the immune system are known, a relatively unexplored area is immunomodulatory lipids. Cutaneous UV exposure changes lipids both locally in the skin, increasing platelet-activating factor (PAF) production and decreasing free triglyceride levels, and systemically reducing adipose tissue mass. There is growing recognition that bioactive lipids and lipid metabolism directly affect immune cell phenotype and function. Manipulation of immunomodulatory lipid pathways are effective strategies in modifying systemic immune responses. Indeed, the PAF pathway is a key initiator of UV-induced immune suppression and antagonism of PAF-receptors restores immune function and reduces skin cancer development in mice. This review focuses on the known effects of UV on lipids and proposes how this may in turn be involved in the modulation of the immune system.

中文翻译:

脂质在紫外线辐射下诱导免疫调节。

紫外线(UV)辐射介导的免疫抑制是赋予日晒对人体健康不利和有益影响的关键机制。抗肿瘤反应的抑制促进了紫外线诱导的皮肤癌的发展和进展。相反,抑制失调的免疫反应促进了光疗治疗皮肤疾病的治疗成功,并被认为是对自身免疫性疾病的紫外线防护的原因。虽然已知一些抑制免疫系统紫外线的分子和细胞机制,但相对未开发的领域是免疫调节脂质。皮肤暴露在紫外线下会改变皮肤中的脂质,从而增加血小板活化因子(PAF)的产生并降低游离甘油三酸酯的水平,并全身性地减少脂肪组织的质量。人们日益认识到,生物活性脂质和脂质代谢会直接影响免疫细胞的表型和功能。操纵免疫调节脂质途径是修饰全身免疫反应的有效策略。实际上,PAF途径是紫外线诱导的免疫抑制的关键引发剂,PAF受体的拮抗作用可恢复免疫功能并减少小鼠皮肤癌的发展。这篇综述着重于紫外线对脂质的已知作用,并提出了紫外线可能如何参与免疫系统的调节。PAF途径是紫外线诱导的免疫抑制的关键引发剂,PAF受体的拮抗作用可恢复免疫功能并减少小鼠皮肤癌的发展。这篇综述着重于紫外线对脂质的已知作用,并提出了紫外线可能如何参与免疫系统的调节。PAF途径是紫外线诱导的免疫抑制的关键引发剂,PAF受体的拮抗作用可恢复免疫功能并减少小鼠皮肤癌的发展。这篇综述着重于紫外线对脂质的已知作用,并提出了紫外线可能如何参与免疫系统的调节。
更新日期:2020-07-15
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