There is a significant interest in identifying clinically effective drug treatment regimens that minimize the de novo evolution of antimicrobial resistance in pathogen populations. However, in vivo studies that vary treatment regimens and directly measure drug resistance evolution are rare. Here, we experimentally investigate the role of drug dose and treatment timing on resistance evolution in an animal model.

中文翻译：

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药物剂量和治疗时间对疟疾模型体内耐药性出现的影响


人们对确定临床有效的药物治疗方案非常感兴趣，这些方案可以最大限度地减少病原体群体中抗菌素耐药性的从头进化。然而，改变治疗方案并直接测量耐药性进化的体内研究很少。在这里，我们通过动物模型实验研究药物剂量和治疗时机对耐药性进化的作用。