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Tumor Necrosis Factor-α, the Pathological Key to Post-Traumatic Epilepsy: A Comprehensive Systematic Review.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-06-01 , DOI: 10.1021/acschemneuro.0c00301
Alina Arulsamy 1 , Mohd Farooq Shaikh 1, 2
Affiliation  

Post-traumatic epilepsy (PTE) is one of the detrimental outcomes of traumatic brain injury (TBI), resulting in recurrent seizures that impact daily life. However, the pathological relationship between PTE and TBI remains unclear, and commonly prescribed antiepileptic drugs (AED) are ineffective against PTE. Fortunately, emerging research implicates neuroinflammation, particularly, tumor necrosis factor-α (TNF-α), as the key mediator for PTE development. Thus, this review aims to examine the available literature regarding the role of TNF-α in PTE pathology and, subsequently, evaluate TNF-α as a possible target for its treatment. A comprehensive literature search was conducted on four databases including PubMed, CINAHL, Embase, and Scopus. Articles with relevance in investigating TNF-α expression in PTE were considered in this review. Critical evaluation of four articles that met the inclusion criteria suggests a proportional relationship between TNF-α expression and seizure susceptibilit and that neutralization or suppression of TNF-α release results in reduced susceptibility to seizures. In conclusion, this review elucidates the importance of TNF-α expression in epileptogenesis postinjury and urges future research to focus more on clinical studies involving TNF-α, which may provide clearer insight into PTE prevention, therefore improving the lives of PTE patients.

中文翻译:

肿瘤坏死因子-α,创伤后癫痫的病理关键:综合系统评价。

创伤后癫痫 (PTE) 是创伤性脑损伤 (TBI) 的有害结果之一,可导致影响日常生活的反复癫痫发作。然而,PTE 与 TBI 之间的病理关系仍不清楚,常用的抗癫痫药物(AED)对 PTE 无效。幸运的是,新兴研究表明神经炎症,特别是肿瘤坏死因子-α (TNF-α),是 PTE 发展的关键介质。因此,本综述旨在检查有关 TNF-α 在 PTE 病理学中作用的现有文献,并随后评估 TNF-α 作为其治疗的可能靶点。对包括 PubMed、CINAHL、Embase 和 Scopus 在内的四个数据库进行了全面的文献检索。本综述考虑了与研究 PTE 中 TNF-α 表达相关的文章。对符合纳入标准的四篇文章进行的严格评估表明,TNF-α 表达与癫痫发作易感性之间存在比例关系,并且中和或抑制 TNF-α 释放导致癫痫发作易感性降低。总之,本综述阐明了 TNF-α 表达在损伤后癫痫发生中的重要性,并敦促未来的研究更多地关注涉及 TNF-α 的临床研究,这可能为 PTE 的预防提供更清晰的见解,从而改善 PTE 患者的生活。
更新日期:2020-07-01
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