Abstract The electrospray ionisation mass spectrometric (ESI-MS) behaviour of various complexes of beryllium have been investigated in the work described in this paper. These beryllium complexes were analysed in situ on a small scale by preparing appropriate molar mixtures of the Be2+ ion with ligands in a range of solvent systems. In view of the toxicity of beryllium compounds, this combinatorial type screening, involving miniscule amounts of material in solution, proved to be a safe strategy to pursue the coordination chemistry of beryllium. A variety of beryllium complexes were generated with various ligands in solutions and subjected to detailed characterisation by ESI-MS. These ligands, containing functional groups or architecture of interest, varied from simple ligands such as the acetate ion to more common beryllium chelators including hydroxy keto ligands (maltol, tropolone), malonic acid, chromotropic acid and citric acid. Generally, there was excellent correlation between the species observed in the mass spectrum and those confirmed to exist in solution by other techniques. This lent strong credence to the ESI-MS methodology used as an efficient analytical technique for the easy screening of a diverse range of potential ligands for the divalent beryllium ion.

中文翻译：

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Be2+ 离子与螯合氧供体配体的配位化学：使用电喷雾质谱的进一步见解

摘要 本文描述的工作研究了各种铍配合物的电喷雾电离质谱 (ESI-MS) 行为。通过在一系列溶剂系统中制备 Be2+ 离子与配体的适当摩尔混合物，对这些铍配合物进行了小规模原位分析。鉴于铍化合物的毒性，这种在溶液中使用微量材料的组合类型筛选被证明是追求铍配位化学的安全策略。各种铍配合物与溶液中的各种配体一起生成，并通过 ESI-MS 进行详细表征。这些配体，包含感兴趣的官能团或结构，从简单的配体（如乙酸根离子）到更常见的铍螯合剂，包括羟基酮配体（麦芽酚、托酚酮）、丙二酸、变色酸和柠檬酸。通常，质谱中观察到的物质与通过其他技术确认存在于溶液中的物质之间存在极好的相关性。这使 ESI-MS 方法成为一种有效的分析技术，可以轻松筛选二价铍离子的各种潜在配体。