Abstract The design of this study was developed to examine the chemical composition, anticholinesterase and anti-inflammatory inhibitory activities of the essential oil of Dipterocarpus cornutus Dyer from Malaysia. Gas chromatography (GC) and gas chromatography/mass spectrometry (GC-MS) analysis of the essential oil revealed 20 components, representing 94.6% of the oil. The major components identified were α-gurjunene (50.6%), α-selinene (8.3%), spathulenol (5.7%), and bicyclogermacrene (5.4%). Anticholinesterase and anti-inflammatory activity were also evaluated using the Ellman method and lipoxygenase (LOX) enzyme, respectively, in which the essential oil revealed weak inhibitory activity against the acetylcholinesterase (AChE) (I%: 30.2%) and butyrylcholinesterase (BChE) (I%: 32.5%), while moderate inhibitory activity was reported in the LOX (I%: 70.2%). The approach adopted in this study and results are reported for the first time which could be useful for the characterization, pharmaceutical and therapeutic applications of the essential oil from Dipterocarpus genus.

中文翻译：

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龙脑香精油的化学成分和生物活性

摘要 本研究旨在检测马来西亚龙脑香精油的化学成分、抗胆碱酯酶和抗炎抑制活性。精油的气相色谱 (GC) 和气相色谱/质谱 (GC-MS) 分析显示 20 种成分，占精油的 94.6%。确定的主要成分是 α-gurjunene (50.6%)、α-selinene (8.3%)、spathulenol (5.7%) 和 bicyclogermacrene (5.4%)。还分别使用 Ellman 方法和脂氧合酶 (LOX) 评估了抗胆碱酯酶和抗炎活性，其中精油显示出对乙酰胆碱酯酶 (AChE) (I%: 30.2%) 和丁酰胆碱酯酶 (BChE) 的弱抑制活性（ I%: 32.5%), 而在 LOX 中报告了中等抑制活性（I%：70.2%）。本研究中采用的方法和结果首次报道，可用于龙脑香属精油的表征、药物和治疗应用。