Abstract Immunotherapy, which utilizes the patient’s own immune system to fight against cancer, further results in durable antitumor responses and reduces metastasis and recurrence, has become one of the most effective and important cancer therapies along with surgery, radiotherapy, and chemotherapy. Nanomaterials with the advantages of large specific surface, delivery function, and controllable surface chemistry are used to deliver antigens or adjuvants, or both, help to boost immune responses with the imaging function or just act as adjuvants themselves and modulate tumor microenvironment (TME). In this review, recent development and applications of nanomaterials for cancer immunotherapy including delivery systems based on nanomaterials, uniting imaging, self-adjuvants, targeting functions, artificial antigen presenting cells, and TME modulation are focused and discussed.

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纳米材料在肿瘤免疫治疗中的新进展及应用

摘要 免疫疗法利用患者自身的免疫系统对抗癌症，进一步产生持久的抗肿瘤反应，减少转移和复发，已成为与手术、放疗、化疗一起成为最有效和最重要的癌症治疗方法之一。纳米材料具有大比表面积、传递功能和可控表面化学等优点，可用于传递抗原或佐剂，或两者兼有，通过成像功能帮助增强免疫反应，或者本身作为佐剂调节肿瘤微环境 (TME)。在这篇综述中，纳米材料用于癌症免疫治疗的最新发展和应用包括基于纳米材料的递送系统、联合成像、自佐剂、靶向功能、人工抗原呈递细胞、