Abstract In canine and feline populations, the number of neoplasm cases continues to increase around the world. Attempts are being made in centres of research to identify new biomarkers that speed up and improve the quality of oncological diagnostics and therapy in human and animal tumour patients. Cyclooxygenase-2 (COX-2) is a promising biomarker with increasing relevance to human oncology, but as yet with less application in veterinary oncology. The expression of COX-2 increases significantly during pathological processes involving inflammation, pain or fever. It is also overexpressed in humans presenting various types of tumours and in selected types of tumours in animals, particularly in dogs. This article discusses the expression of COX-2 in canine and feline tumours, the importance of COX-2 as a biomarker with diagnostic, therapeutic, prognostic and predictive relevance in oncology, and the clinical significance of inhibiting COX-2 overexpression in tumours.

中文翻译：

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Cyclooxygenase-2 作为在小动物肿瘤学中具有诊断、治疗、预后和预测相关性的生物标志物

摘要 在犬科和猫科动物中，全球肿瘤病例数持续增加。研究中心正在尝试确定新的生物标志物，以加快和提高人类和动物肿瘤患者的肿瘤诊断和治疗质量。Cyclooxygenase-2 (COX-2) 是一种很有前景的生物标志物，与人类肿瘤学的相关性越来越大，但在兽医肿瘤学中的应用较少。在涉及炎症、疼痛或发烧的病理过程中，COX-2 的表达显着增加。它还在呈现各种类型肿瘤的人类和动物的选定类型肿瘤中过度表达，特别是在狗中。本文讨论了 COX-2 在犬和猫肿瘤中的表达，以及 COX-2 作为具有诊断、治疗、