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Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties
Heterocyclic Communications ( IF 1.3 ) Pub Date : 2020-04-03 , DOI: 10.1515/hc-2020-0009
Soheila Asadpour Behzadi 1 , Enayatollah Sheikhhosseini 1 , Sayed Ali Ahmadi 1 , Dadkhoda Ghazanfari 1 , Mohammadreza Akhgar 1
Affiliation  

Abstract A series of novel tetracoumarin derivatives (3a-f) were prepared using the reaction of ether functionalized dibenzaldehyde with 4-hydroxycoumarin in the presence of sodium acetate. The structure of compounds was validated by IR, NMR, and CHN analyzes. Antimicrobial (antibacterial and antifungal) activity was studied on the basis of the minimum bactericidal concentration, minimum inhibitory concentration and inhibitory zone diameter. Favorable biological activity was found in compound 3f.

中文翻译:

含醚部分的新型生物四香豆素衍生物的合成与表征

摘要 在乙酸钠存在下,醚官能化二苯甲醛与 4-羟基香豆素反应制备了一系列新型四香豆素衍生物 (3a-f)。化合物的结构通过 IR、NMR 和 CHN 分析进行验证。根据最低杀菌浓度、最低抑菌浓度和抑菌圈直径研究抗菌(抗菌和抗真菌)活性。在化合物3f中发现了有利的生物活性。
更新日期:2020-04-03
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