Abstract Coumarin sulfonamide is a heterocyclic pharmacophore and an important structural motif which is a core and integral part of different therapeutic scaffolds and analogues. Coumarin sulfonamides are privileged and pivotal templates which have a broad spectrum of applications in the fields of medicine, pharmacology and pharmaceutics. Coumarin sulfonamide exhibited versatile and myriad biomedical activities such as anti-bacterial, antiviral, antifungal, anti-inflammatory and anti-cancer. This review article focuses on the structural features of coumarin sulfonamide derivatives in the treatment of different lethal diseases on the basis of structure-activity relationships (SAR). The plethora of research cited in this review article summarizes and discusses the various substitutions around the coumarin sulfonamide nucleus which have provided a wide spectrum of biological activities and therapeutic potential that has proved attractive to many researchers looking to exploit the coumarin sulfonamide skeleton for drug discovery and the development of novel therapeutic agents.

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香豆素磺酰胺衍生物：一类新兴的治疗药物

摘要 香豆素磺酰胺是杂环药效团和重要的结构基序，是不同治疗支架和类似物的核心和组成部分。香豆素磺酰胺是一种特殊的关键模板，在医学、药理学和药剂学领域具有广泛的应用。香豆素磺酰胺具有多种生物医学活性，如抗菌、抗病毒、抗真菌、抗炎和抗癌。这篇综述文章根据构效关系（SAR）重点研究香豆素磺酰胺衍生物在治疗不同致死性疾病中的结构特征。