Phytochemical investigation of Anneslea fragrans twigs resulted in the discovery of fragranol A (1), a new class of structurally challenging and sterically hindered “spiro-triflavanoid” type compound possessing an unprecedented carbon skeleton. Fragranol A (1) consists of 45 carbons having six chiral carbons, including two spiro-chiral centers. Structural elucidation of 1 was achieved by HRFABMS, 1D and 2D NMR, analysis of spatial anisotropic effects, and quantum ECD calculations. A plausible biogenetic pathway of 1 is also proposed.

中文翻译：

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Fragranol A：来自Anneslea fragrans的具有前所未有碳骨架的新型螺-三黄烷类杂化物

对Anneslea fragrans树枝进行植物化学研究后，发现了fragranol A（1），这是一类具有前所未有的碳骨架的结构挑战性且受空间限制的新型“螺-三黄烷类”化合物。香气醇A（1）由具有六个手性碳的45个碳组成，包括两个螺-手性中心。通过HRFABMS，1D和2D NMR，空间各向异性效应分析以及量子ECD计算，实现了1的结构解析。还提出了一个合理的生物遗传途径1。