Abstract Three novel ruthenium nitrosyl complexes [ Ru(NO)Cl3(InicMe)2] (1b), [RuNOCl3(NicEt)2] (1c) and [RuNOCl3(NicMe)2] (1d) (InicMe = methyl isonicotinate, NicEt = ethyl nicotinate, NicMe = = methyl nicotinate)were prepared and crystal structure of the complexes were determined by single crystal XRD analysis. In all complexes, the organic ligands are coordinated by a pyridine nitrogen atom and located in trans-position each to other and in cis-position to NO group. In the crystal package of all compounds stacking interactions of two types were determined: πarene-πarene and πCOO-πarene stacking. Finally, cytotoxicity of the compounds was tested on Hep2 and HepG2 cell lines. In the set of similar compounds mer-[RuNO(L)2Cl3] (L = Py, γ-Pic, β-Pic, Inic-Alk, Nic-Alk), complexes with iso-nicotinic acid esters are the most toxic, while nicotinic acid derivatives are less toxic and compared with pyridine complex.

中文翻译：

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通过亚硝酰基钌配合物中的仿生配体调节细胞毒活性

摘要 三种新型亚硝酰基钌配合物 [Ru(NO)Cl3(InicMe)2] (1b)、[RuNOCl3(NicEt)2] (1c) 和 [RuNOCl3(NicMe)2] (1d)（InicMe = 异烟酸甲酯，NicEt =制备了烟酸乙酯、NicMe = = 烟酸甲酯)，并通过单晶 XRD 分析确定了配合物的晶体结构。在所有配合物中，有机配体由吡啶氮原子配位并位于彼此的反式位置和顺式位置至 NO 基团。在所有化合物的晶体包中确定了两种类型的堆积相互作用：π芳烃-π芳烃和πCOO-π芳烃堆积。最后，在 Hep2 和 HepG2 细胞系上测试了化合物的细胞毒性。在一组类似的化合物 mer-[RuNO(L)2Cl3] (L = Py, γ-Pic, β-Pic, Inic-Alk, Nic-Alk) 中，与异烟酸酯的复合物毒性最大，