Escherichia coli ST131 clone and H30-R/H30-Rx subclones are the most common multidrug-resistant high-risk clones in UTIs. Antimicrobial susceptibility of fosfomycin was compared to five other agents in consecutively collected 299 urinary isolates using the agar dilution method. Prevalence of the ST131 clone and the occurrence of blaCTX-M were also investigated. Overall resistance to fosfomycin, cefuroxime, and ceftriaxone were 2.7%, 35.4%, and 30.1% respectively. fosA, fosA3, and fosC2 genes were not detected. In isolates resistant to ciprofloxacin (34.7%), the prevalence of ST131 clone was 31.7%, of which 81.8% belonged to H30-R and 66.7% to H30-Rx subclones. None of the isolates of the ST131 clone were resistant to fosfomycin. However, bla_CTX-M occurred in 57.6% of the isolates among this clone, 62.9% in H30-R and 68.2% in H30-Rx subclones. The results of this study suggest that fosfomycin resistance is not prevalent in urinary isolates, however, bla_CTX-M positive ST131 clone is quite common.

大肠杆菌ST131克隆和H30-R / H30-Rx亚克隆是UTI中最常见的耐多药高危克隆。使用琼脂稀释法，在连续收集的299个尿液分离物中，比较了磷霉素的抗菌敏感性和其他五种药物的敏感性。还研究了ST131克隆的患病率和blaCTX -M的发生。对磷霉素，头孢呋辛和头孢曲松的总体耐药性分别为2.7％，35.4％和30.1％。没有检测到fosA，fosA3和fosC2基因。在对环丙沙星耐药的分离株（34.7％）中，ST131克隆的患病率为31.7％，其中81.8％属于H30-R，66.7％属于H30-Rx亚克隆。ST131克隆的分离株均未对磷霉素产生抗药性。然而在该克隆中，bla _CTX-M出现在57.6％的分离株中，H30-R中为62.9％，H30-Rx亚克隆中为68.2％。这项研究的结果表明，磷霉素抗性在尿分离株中并不普遍，但是，bla _CTX-M 阳性的ST131克隆非常普遍。