Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2020-06-02 , DOI: 10.1016/j.bmcl.2020.127301 Lauren Fields 1 , Whitney R Craig 2 , Clair A Huffine 3 , Catherine F Allen 4 , Leah M Bouthillette 1 , Jacob C Chappell 1 , Jacob T Shumate 1 , Amanda L Wolfe 1
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The dramatic increase in bacterial resistance over the past three decades has greatly reduced the effectiveness of nearly all clinical antibiotics, bringing infectious disease to the forefront as a dire threat to global health. To combat these infections, adjuvant therapies have emerged as a way to reactivate known antibiotics against resistant pathogens. Herein, we report the evaluation of simplified α-pyrone adjuvants capable of potentiating penicillin G against Pseudomonas aeruginosa, a Gram-negative pathogen whose multidrug-resistant strains have been labeled by the Centers for Disease Control and Prevention as a serious threat to public health.
中文翻译：
能够增强针对铜绿假单胞菌的青霉素G的短链α-吡喃酮。
在过去的三十年中，细菌耐药性的急剧增加大大降低了几乎所有临床抗生素的有效性，将传染病列为最严重威胁全球健康的疾病。为了对抗这些感染，已经出现了辅助疗法，作为使已知的抗生素抵抗耐药病原体重新活化的方法。本文中，我们报告了能够增强青霉素G对抗铜绿假单胞菌的简化α-吡喃酮佐剂的评估，铜绿假单胞菌是革兰氏阴性病原体，其多重耐药菌株已被疾病控制和预防中心标记为对公共卫生的严重威胁。
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