Anxiety disorders appear to involve distinct neurobiological mechanisms and several medications are available against this mental health problem. However, pharmacological therapeutic approaches display undesirable side effects for patients, particularly when long-term therapy is required. Some evidences have suggested that Coriandrum sativum extract (CSE) provide sedative and anxiolytic effects. We investigate if CSE could attenuate anxiety-like behaviors induced by novelty and alarm substance exposures in zebrafish. Adult zebrafish were injected with vehicle, clonazepam, or CSE (25, 50 or 100 mg/kg) and submitted to novel tank test. At the end, saline or alarm substance was added and anxiety-like responses were recorded. Twenty-four hours after, fish were submitted to the light/dark test. Novelty associated with alarm substance exposure decreased distance traveled and total time mobile in novel tank, and CSE (at 50 and 100 mg/kg) prevented these alterations similarly to clonazepam. Alarm substance reduced the time spent in white compartment (p = 0.0193 as compared with vehicle group). Clonazepam and CSE prevented this anxiogenic effect of alarm substance. CSE presents anxiolytic effects against alarm substance-induced locomotor and anxiogenic responses similarly to clonazepam. These data corroborate with the use of this plant in traditional medicine and provides a putative new pharmacological intervention for anxiety disorders.

中文翻译：

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香菜提取物可防止成年斑马鱼中警觉物质引起的恐惧和焦虑反应。

焦虑症似乎涉及不同的神经生物学机制，针对这种精神健康问题有几种药物可供使用。但是，药理学治疗方法对患者表现出不良副作用，尤其是在需要长期治疗时。一些证据表明，Cor提取物（CSE）具有镇静和抗焦虑作用。我们调查了CSE是否可以减轻斑马鱼中新颖性和警报物质暴露引起的焦虑样行为。给成年斑马鱼注射媒介物，氯硝西am或CSE（25、50或100 mg / kg），然后进行新型水箱试验。最后，加入盐水或警报物质，并记录焦虑样反应。24小时后，将鱼进行明/暗测试。与报警物质接触有关的新颖性降低了新型药罐的行进距离和总移动时间，而CSE（50和100 mg / kg）可与氯硝西am类似地阻止这些改变。警报物质减少了在白色隔间中花费的时间（p =与车辆组相比为0.0193）。氯硝西am和CSE阻止了警报物质的这种抗焦虑作用。CSE与氯硝西am相似，具有抗警报物质引起的运动和焦虑发生的抗焦虑作用。这些数据证实了这种植物在传统医学中的使用，并为焦虑症提供了一种新的药理干预手段。