The explanation of hypersensitivity reactions has long relied on the classification of Gell and Coombs, originally proposed in the 1960s. However, their concepts were predated by other authors by at least 50 years. A 21st century pediatric allergy clinic provides multiple examples of these basic concepts on a daily basis. We review classic and less classic examples of the original criteria, highlight where current disease pathophysiology does not always fit the original model, and provide updated language for common and uncommon immunologically driven hypersensitivity diseases.

中文翻译：

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超敏反应：儿科过敏诊所的日常发生

对超敏反应的解释长期以来一直依赖于 1960 年代最初提出的 Gell 和 Coombs 分类。然而，他们的概念早于其他作者至少 50 年。一家 21 世纪的儿科过敏诊所每天都会提供这些基本概念的多个示例。我们回顾了原始标准的经典和不太经典的例子，强调了当前疾病病理生理学并不总是适合原始模型的地方，并为常见和不常见的免疫驱动的过敏性疾病提供更新的语言。