Epidemiological studies have shown that exposure to particulate matter (PM) is associated with adverse health effects. Inhalation of fine particulate matter (PM2.5) is associated with elevated pulmonary diseases. However, the molecular mechanism underlying the initiation of lung inflammation following inhalation is unclear. In this study, we investigated the beneficial effects of two probiotics, Lactobacillus casei HY2782 and Bifidobacterium lactis HY8002, against PM-induced pulmonary inflammation. Model mice were subjected to chronic exposure of PM2.5. The results showed that PM2.5 enhanced oxidative stress and led to Th2 cytokine responses in the mice. PM2.5-exposed mice were orally administered with HY2782 and HY8002 from the day of first exposure to the end point of the study. The results showed that HY2782 ameliorated PM 2.5 exposure-enhanced leukocyte migration and activation of proinflammatory cytokines. HY2782 and HY8002 also prevented exacerbation of eosinophil and neutrophil infiltration in the bronchoalveolar lavage fluid. HY2782 and HY8002 significantly increased scavenging of PM2.5-induced reactive oxygen species and activated superoxide dismutase and catalase activity in the blood. These results indicate that the probiotics HY2782 and HY8002 protect against PM-induced pulmonary inflammation.

中文翻译：

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乳酸杆菌HY2782和双歧杆菌HY8002降低了小鼠慢性PM2.5吸入诱导的气道高反应性。

流行病学研究表明，接触颗粒物（PM）与不良健康影响相关。吸入细颗粒物（PM2.5）与肺部疾病增加有关。但是，吸入后引发肺部炎症的分子机制尚不清楚。在这项研究中，我们调查了两种益生菌，干酪乳杆菌HY2782和乳酸双歧杆菌的有益作用。HY8002，针对PM引起的肺部炎症。使模型小鼠长期暴露于PM2.5。结果表明，PM2.5增强了小鼠的氧化应激并导致Th2细胞因子反应。从第一次接触到研究结束，从PM2.5暴露的小鼠开始口服HY2782和HY8002。结果表明，HY2782改善了PM 2.5暴露增强的白细胞迁移和促炎细胞因子的激活。HY2782和HY8002还可以防止支气管肺泡灌洗液中嗜酸性粒细胞和嗜中性粒细胞浸润的加剧。HY2782和HY8002显着提高了PM2.5诱导的活性氧清除能力以及血液中活化的超氧化物歧化酶和过氧化氢酶的活性。