This study was aimed at evaluating a potential association between blood pressure variation and acute mountain sickness (AMS) during acute exposure to normobaric hypoxia. A total of 77 healthy subjects (43 males, 34 females) were exposed to a simulated altitude of 4500 m for 12 hours. Peripheral oxygen saturation, heart rate, systemic blood pressure, and Lake Louise AMS scores were recorded before and during (30 minutes, 3, 6, 9, and 12 hours) hypoxic exposure. Blood pressure dips were observed at 3-hour mark. However, systolic blood pressure fell more pronounced from baseline during the initial 30 minutes in normobaric hypoxia (−17.5 vs. −11.0 mmHg, p = 0.01) in subjects suffering from AMS (AMS⁺; n = 56) than in those remaining unaffected from AMS (AMS⁻; n = 21); values did not differ between groups over the subsequent time course. Our data may suggest a transient autonomic dysfunction resulting in a more pronounced blood pressure drop during initial hypoxic exposure in AMS⁺ compared with AMS⁻ subjects.

中文翻译：

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在常压低氧（4500 m）暴露12小时期间的全身血压变化。

这项研究旨在评估在急性暴露于常压低氧期间血压变化与急性高山病（AMS）之间的潜在关联。共有77位健康受试者（43位男性，34位女性）在4500 m的模拟海拔下暴露12小时。在缺氧暴露之前和期间（30分钟，3、6、9和12小时）记录外周血氧饱和度，心率，全身血压和路易斯湖AMS评分。在3小时标记处观察到血压下降。但是，在常压性缺氧的最初30分钟内，收缩压从基线下降得更为明显（-17.5 vs.-11.0 mmHg，p  = 0.01），而AMS患者（AMS ⁺ ; n  = 56）则比那些未受影响的患者更明显。 AMS（AMS⁻ ; n  = 21）；在随后的时间过程中，各组之间的值没有差异。在AMS最初缺氧过程我们的数据可能暗示导致更明显的血压下降短暂植物神经功能紊乱⁺与AMS相比^-科目。