Complications of central nervous system in type 2 diabetes mellitus (T2DM) often lead to cognitive impairment and seriously affect the quality of life. However, there is no individualized disease model. Urine-derived stem cells can be an ideal source for generating human induced pluripotent stem cells (hiPSCs) and progenitors, as they are easily accessible, noninvasive, and universally available. In our research, we differentiated urine-derived hiPSCs into neuron (N), astrocyte (A), and microvascular endothelial cells (E) from a T2DM patient. Next step, we intend to coculture these three cells together in a 3D system to create a new disease model in vitro, which may simulate the cerebral microenvironment of DM, for future study of its pathogenesis and precision medical treatment.

中文翻译：

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尿液诱导的多能干细胞向糖尿病患者神经元，星形胶质细胞和微血管内皮细胞的分化。

2型糖尿病（T2DM）的中枢神经系统并发症通常会导致认知障碍并严重影响生活质量。但是，没有个体化的疾病模型。尿液衍生的干细胞可以很容易获得，无创且普遍使用，因此是生成人诱导的多能干细胞（hiPSC）和祖细胞的理想来源。在我们的研究中，我们将T2DM患者的尿液衍生的hiPSCs分为神经元（N），星形胶质细胞（A）和微血管内皮细胞（E）。下一步，我们打算将这三个细胞在3D系统中共同培养，以在体外创建新的疾病模型，该模型可以模拟DM的大脑微环境，以供将来对其发病机理和精确医学治疗进行研究。