Objective. We here evaluated the association between human papillomavirus (HPV) infection and vaginal infections, including bacterial vaginosis (BV), trichomonas vaginalis (TV), and vulvovaginal candidiasis (VVC). Methods. A total of 4,449 women were enrolled in this study and given gynecological examinations. HPV genotyping and viral load determination were performed using a real-time PCR. Vaginal infections were diagnosed using wet mounts of vaginal secretions, gram-stained vaginal secretion smears, and chemical enzyme kits. Results. In this study, the overall HPV-positive rate was 25.06%, and vaginal infection tended to occur in women with HPV infection (). HPV infection tended to occur in BV- and TV-positive women () and not in women with microecological disorders, intermediate type BV, VVC, or coinfection (). The most common genotypes were HPV58 and HPV53 in women with normal vaginal microecology and HPV16 and HPV52 in the women suffering from vaginal infection. The viral loads among groups for HPV16 and HPV52 showed no statistically significant differences (; ). Conclusions. Our study revealed that BV and TV are associated with HPV infection, especially high-risk HPV infection, while VVC has no association with HPV infection. Further studies are needed to explore the detailed mechanism.

中文翻译：

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阴道感染与人乳头瘤病毒类型和病毒载量的关联：基于 4449 例妇科门诊患者的临床研究

客观。我们在这里评估了人乳头瘤病毒 (HPV) 感染和阴道感染之间的关联，包括细菌性阴道病 (BV)、阴道毛滴虫 (TV) 和外阴阴道念珠菌病 (VVC)。方法。共有 4,449 名女性参加了这项研究并接受了妇科检查。使用实时 PCR 进行 HPV 基因分型和病毒载量测定。使用阴道分泌物湿片、革兰染色阴道分泌物涂片和化学酶试剂盒诊断阴道感染。结果。本研究总体HPV阳性率为25.06%，HPV感染女性易发生阴道感染（）。HPV 感染往往发生在 BV 和 TV 阳性的女性中 ( )而在患有微生态疾病、中间型 BV、VVC 或合并感染的女性中则不然（）。在阴道微生态正常的女性中最常见的基因型是 HPV58 和 HPV53，在患有阴道感染的女性中最常见的基因型是 HPV16 和 HPV52。HPV16 和 HPV52 组之间的病毒载量没有显示出统计学上的显着差异（; ）。结论。我们的研究表明BV和TV与HPV感染有关，尤其是高危HPV感染，而VVC与HPV感染无关。需要进一步的研究来探索详细的机制。