Because lignin is a macromolecule that is a sustainable source of aromatic compounds, model substrates are commonly used to increase our understanding of its complex structure. However, few methods have been described for the synthesis of these models. Herein, we describe a new route towards the synthesis of β-O-4 lignin models by intermolecular O–H insertion reactions with simple and stable diazocarbonyls. The benefits of this developed method were shorter reaction times and high yields, as well as mild and environmentally friendly conditions.

中文翻译：

---

通过将稳定的2-重氮-1,3-二羰基插入OH键，一锅合成β-O-4木质素模型。

由于木质素是可持久提供芳香化合物的大分子，因此通常使用模型底物来增进我们对其复杂结构的了解。但是，很少有方法描述这些模型的综合。在这里，我们描述了一种通过简单和稳定的重氮羰基分子间的OH插入反应合成β-O-4木质素模型的新途径。这种改进方法的优点是反应时间短，产率高，以及温和和环保的条件。