Pancreatic cancer (PC) is one of the most lethal cancers, with frequent local therapy resistance and dismal 5-year survival rate. To date, surgical resection remains to be the only treatment option offering potential cure. Unfortunately, at diagnosis, the majority of patients demonstrate varying levels of vascular infiltration, which can contraindicate surgical resection. Patients unsuitable for immediate resection are further divided into locally advanced (LA) and borderline resectable (BR), with different treatment goals and therapeutic designs. Accurate definition of resectability is thus critical for PC patients, yet the existing methods to determine resectability rely on descriptive abutment to surrounding vessels rather than quantitative geometric characterization. Here, we aim to introduce a novel intra-subject object-space support-vector-machine (OsSVM) method to quantitatively characterize the degree of vascular involvement—the main factor determining the PC resectabili...

中文翻译：

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量化胰腺癌中的血管侵犯-基于对比CT的手术可切除性评估方法

胰腺癌（PC）是最致命的癌症之一，具有频繁的局部治疗耐药性和令人沮丧的5年生存率。迄今为止，手术切除仍是唯一可提供潜在治愈的治疗选择。不幸的是，在诊断时，大多数患者表现出不同程度的血管浸润，这可能不利于手术切除。不适合立即切除的患者可进一步分为局部晚期（LA）和边缘可切除（BR），具有不同的治疗目标和治疗方案。因此，可切除性的准确定义对于PC患者至关重要，但是确定可切除性的现有方法依赖于周围血管的描述性基台，而不是定量的几何表征。这里，