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Targeting specific cell organelles with different-faceted nanocrystals that are selectively recognized by organelle-targeting peptides.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-06-01 , DOI: 10.1039/d0cc02930k
Qilin Yu 1 , Guizhu Wu , Tong Zhang , Xudong Zhao , Zhen Zhou , Lu Liu , Wei Chen , Pedro J J Alvarez
Affiliation  

Targeting specific cellular organelles is an elusive therapeutic goal that could be achieved by manipulating nanocrystal facets. As proof of concept, different facet-engineered nanonods (high-energy (001) CdS and (001) CdSe, and low-energy (101) CdS and (110) CdSe) exploited selective binding by organelle-targeting peptides and subsequent intracellular protein sorting to inhibit specific organelles without significant cytotoxicity.

中文翻译:

用不同面的纳米晶体靶向特定的细胞器,这些晶体可以被靶向细胞器的肽选择性识别。

靶向特定的细胞器是一个难以捉摸的治疗目标,可以通过操纵纳米晶面来实现。作为概念验证,不同的方面工程化的纳米点(高能(001)CdS和(001)CdSe和低能(101)CdS和(110)CdSe)利用细胞器靶向肽和随后的细胞内蛋白进行选择性结合分选以抑制特定细胞器而没有明显的细胞毒性。
更新日期:2020-07-09
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