Objective: Evidence regarding comedication among individuals with ADHD is lacking, especially in adults. This study investigated comedication and polypharmacy with ADHD medications in adults. Method: We identified adults dispensed with ADHD medications during 2013 in Sweden and matched them to controls. Logistic regression was used to calculate odds ratios (ORs) of receiving other medications. Results: Individuals receiving ADHD medications had higher risk of receiving any major classes of somatic medications (ORs ranged from 4.1, 95% confidence interval [CI] = [4.0, 4.3], to 7.4, 95% CI = [6.5, 8.5] across age groups). They were more likely to receive respiratory system, alimentary tract and metabolic system, and cardiovascular system medications. In addition, they had higher risk of receiving any other psychotropic medications. The proportion of polypharmacy with five or more medication classes increased from 10.1% to 60.4% from 18 to 64 years. Conclusion: Comedication was more common in adults receiving ADHD medications. Potential benefits and harms of comedication and polypharmacy require further research. (J. of Att. Dis. XXXX; XX[X] XX-XX)

目标：缺乏关于 ADHD 患者的药物治疗的证据，尤其是在成人中。本研究调查了成人多动症药物的联合用药和多药治疗。方法：我们确定了 2013 年在瑞典使用 ADHD 药物的成年人，并将他们与对照组进行了匹配。Logistic 回归用于计算接受其他药物治疗的优势比 (OR)。结果：接受 ADHD 药物治疗的个体接受任何主要类别的躯体药物治疗的风险更高（OR 范围从 4.1，95% 置信区间 [CI] = [4.0, 4.3] 到 7.4，95% CI = [6.5, 8.5] 跨年龄组）。他们更有可能接受呼吸系统、消化道和代谢系统以及心血管系统药物治疗。此外，他们接受任何其他精神药物的风险更高。具有五个或更多药物类别的综合用药比例从 18 至 64 岁从 10.1% 增加到 60.4%。结论：在接受 ADHD 药物治疗的成年人中，喜剧更常见。喜剧和多药治疗的潜在益处和危害需要进一步研究。(J. of Att. Dis. XXXX; XX [ X ]XX-XX)