Rodent studies propose potential mechanisms linking excessive drinking and pain hypersensitivity (hyperalgesia), such that stress hormones (i.e. epinephrine and cortisol) mediate induction and maintenance of alcohol withdrawal-induced hyperalgesia. The first aim of this study was to examine whether hyperalgesia would occur within 48 h after a drinking episode in healthy young adult binge drinkers. The second was to examine whether stress hormones and negative effect would be associated with binge drinking or alcohol withdrawal-associated hyperalgesia.

中文翻译：

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年轻成人酗酒者饮酒发作后的痛觉过敏：一项横断面研究。

啮齿动物研究提出了将过度饮酒和疼痛过敏（痛觉过敏）联系起来的潜在机制，例如应激激素（即肾上腺素和皮质醇）介导酒精戒断引起的痛觉过敏的诱导和维持。本研究的第一个目的是检查健康的年轻成年暴饮者饮酒后 48 小时内是否会出现痛觉过敏。第二个是检查压力荷尔蒙和负面影响是否与暴饮暴食或酒精戒断相关的痛觉过敏有关。